Gene information
Official symbol TFPI
Official full name tissue factor pathway inhibitor
Gene type protein-coding gene
Chromosome2q32.1
Alias symbolEPI; TFI; TFPI1
Previous symbolLACI
Resources
Entrez Gene 7035
HGNC HGNC:11760
Ensembl ENSG00000003436
Vega OTTHUMG00000132634
UCSC uc002upy.4
GO terms: 40 records
GO Description Category LogP Number of genes Detail
GO:0004857 enzyme inhibitor activity GO Molecular Functions -18.4005452 35 More
GO:0004866 endopeptidase inhibitor activity GO Molecular Functions -20.0646267 27 More
GO:0004867 serine-type endopeptidase inhibitor activity GO Molecular Functions -8.20238048 12 More
GO:0007596 blood coagulation GO Biological Processes -44.7281461 45 More
GO:0007599 hemostasis GO Biological Processes -44.1075001 45 More
GO:0009611 response to wounding GO Biological Processes -63.1714102 77 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0010466 negative regulation of peptidase activity GO Biological Processes -24.1438543 35 More
GO:0010951 negative regulation of endopeptidase activity GO Biological Processes -24.7873219 35 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030193 regulation of blood coagulation GO Biological Processes -37.6853179 30 More
GO:0030195 negative regulation of blood coagulation GO Biological Processes -29.1940441 22 More
GO:0030414 peptidase inhibitor activity GO Molecular Functions -19.6181890 27 More
GO:0031225 anchored component of membrane GO Cellular Components -4.51589396 20 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0032870 cellular response to hormone stimulus GO Biological Processes -24.7707938 79 More
GO:0042060 wound healing GO Biological Processes -56.2139708 65 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0044853 plasma membrane raft GO Cellular Components -18.4542052 33 More
GO:0045121 membrane raft GO Cellular Components -30.0775030 71 More
GO:0045861 negative regulation of proteolysis GO Biological Processes -27.9905009 43 More
GO:0048545 response to steroid hormone GO Biological Processes -20.1914989 32 More
GO:0050817 coagulation GO Biological Processes -44.4773041 45 More
GO:0050818 regulation of coagulation GO Biological Processes -40.0839917 32 More
GO:0050819 negative regulation of coagulation GO Biological Processes -31.8350192 24 More
GO:0050878 regulation of body fluid levels GO Biological Processes -57.9546976 69 More
GO:0051346 negative regulation of hydrolase activity GO Biological Processes -26.0030636 42 More
GO:0052547 regulation of peptidase activity GO Biological Processes -35.5643317 55 More
GO:0052548 regulation of endopeptidase activity GO Biological Processes -34.9486589 53 More
GO:0061041 regulation of wound healing GO Biological Processes -35.8633788 36 More
GO:0061045 negative regulation of wound healing GO Biological Processes -28.2986689 25 More
GO:0061134 peptidase regulator activity GO Molecular Functions -19.3582235 29 More
GO:0061135 endopeptidase regulator activity GO Molecular Functions -19.1908633 27 More
GO:0071383 cellular response to steroid hormone stimulus GO Biological Processes -3.35454241 16 More
GO:0071396 cellular response to lipid GO Biological Processes -37.0669488 98 More
GO:0098857 membrane microdomain GO Cellular Components -30.8181788 72 More
GO:1900046 regulation of hemostasis GO Biological Processes -39.0044157 31 More
GO:1900047 negative regulation of hemostasis GO Biological Processes -30.8008788 23 More
GO:1903034 regulation of response to wounding GO Biological Processes -34.9293555 38 More
GO:1903035 negative regulation of response to wounding GO Biological Processes -27.3379640 26 More
KEGG pathways: 1 record
KEGG Description Category LogP Number of genes Detail
hsa04610 Complement and coagulation cascades KEGG Pathway -50.1154932 39 More
Drug-Gene interaction
view
Related drugs: 10 records
Related studies: 4 records
Molecular factor Omics type Application Objective MI type Reference
tissue factor pathway inhibitor proteomics myocardial infarction[diagnosis] myocardial infarction Freeburn JC et al. Br J Haematol. 1998
tissue factor pathway inhibitor proteomics no-reflow phenomenon[prognosis (bad)] acute myocardial infarction Xu P et al. Zhonghua Xin Xue Guan Bing Za Zhi. 2008
tissue factor pathway inhibitor proteomics myocardial infarction[diagnosis] myocardial infarction Winckers K et al. J Thromb Haemost. 2011
tissue factor pathway inhibitor proteomics clopidogrel[treatment (pharmacotherapy)] acute myocardial infarction Boinska J et al. Platelets. 2019
All rights reserved: Soochow University Center for Systems Biology